Mouse anti Human CD69:StarBright Violet 515

货号：MCA2806SBV515

规格：100 Tests/0.5ml

市场价格：3808

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD69

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：FN50

荧光染料：StarBright Violet 515

类型:	单抗	同型对照：	IgG2a
浓度：		用法：	5 µL/test(Flow)
免疫原性：	Activated human B-cells.

Mouse anti Human CD69 antibody, clone FN50recognizes the human early activation antigen CD69, also known as activation inducer molecule (AIM), Early T-cell activation antigen p60, EA1 or MLR-3. CD69 is a 199 amino acid single pass type II transmembrane glycoprotein of ~30 kDa containing a singleC-type lectin domainand a single potentialN-glycosylation site. CD69 is expressed as a disulphide bond linked homodimer of ~60 kDa (López-Cabreraet al.1993).CD69 is a marker of early activation expressed by B and T lymphocytes, natural killer cells(Werfel<et al.<="" em="" style="box-sizing: border-box;">1997), neutrophils, thymocytes and platelets (Gaviolet al.1992). Expression of CD69 is rapidly induced on activation by infection or chronic inflamation (Sanchoet al.2005). Multiple dimeric glycoforms of CD69 can be formed through differential glycosylation of the monomeric subunits (Vanceet al.1997).Mouse anti Human CD69 , clone FN50 is useful for the detection of CD69 by flow cytometry and immunohistochemistry on frozen tissue sections.

数据

Figure A. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488). Figure B. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488) and StarBright Violet 515 conjugated Mouse anti Human CD69 (MCA2806SBV515). All experiments performed on PBMCs extracted from human blood stimulated with PHA and LPS for 48 hours, gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on theZE5 Cell Analyzer.

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参考文献：

1. Holte, H.et al.(1989) Ki67 and 4F2 antigen expression as well as DNA synthesis predict survival at relapse/tumour progression in low-grade B-cell lymphoma.Int J Cancer. 44 (6): 975-80.2. Herberth, M.et al.(2010) Differential effects on T-cell function following exposure to serum from schizophrenia smokers.Mol Psychiatry. 15 (4): 364-71.3. Schaeuble, K.et al.(2011) Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration.J Immunol. 187 (11): 5645-52.4. Sela, M.et al.(2011) Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.EMBO J. 30 (15): 3160-72.5. Garbe, Y.et al.(2011) Semiallogenic fusions of MSI(+) tumor cells and activated B cells induce MSI-specific T cell responses.BMC Cancer. 11: 410.6. Schwitalle, Y.et al.(2004) Immunogenic peptides generated by frameshift mutations in DNA mismatch repair-deficient cancer cells.Cancer Immun. 4: 14.7. Sutavani, R.V.et al.(2013) CD55 Costimulation Induces Differentiation of a Discrete T Regulatory Type 1 Cell Population with a Stable Phenotype.J Immunol. 191: 5895-903.8. Walter, G.J.et al.(2013) Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells.Arthritis Rheum. 65: 627-38.9. Kuric, E.et al.(2017) Demonstration of Tissue Resident Memory CD8 T Cells in Insulitic Lesions in Adult Patients with Recent-Onset Type 1 Diabetes.Am J Pathol. 187 (3): 581-8.10. Karnell, F.G.et al.(2017) Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation.Clin Exp Immunol. 189 (3): 268-278.

技术参数

产品应用 Flow

产品类型 单克隆抗体

推荐用于 Flow

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