Mouse anti Human Complement Factor I 伯乐人Complement Factor I 抗体 MCA2615-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse anti Human Complement Factor I 伯乐人Complement Factor I 抗体 MCA2615

2024-10-29

Mouse anti Human Complement Factor I

货号：MCA2615

规格：0.1 mg

市场价格：6401

产品类型：流式抗体

品牌：Bio-Rad

抗原：Complement Factor I

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：052.11.3 (3R/8)

荧光染料：Purified

产品介绍
Mouse anti Human Complement Factor I antibody, clone 052.11.3 (3R/8)recognizes complement factor I, a member of the peptidase S1 family present in the blood plasma. Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors.Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome.Mouse anti Human Complement Factor I antibody, clone 3R/8 blocks function of complement factor I.Removal of Sodium Azide is recommended prior to use in functional assays.
产品详情
Target Species	Human
Product Form	Purified Ig - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution	Borate buffered saline
Immunogen	Native human factor I from serum.
Approx. Protein Concentrations	Current, batch-specific concentration 1.20 mg/ml
Preservative Stabilisers	0.1%Sodium Azide (NaN3)
Regulatory	For research purposes only
Guarantee	Guaranteed until date of expiry. Please see product label.
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√	1/500	1/4000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
Dragon-Durey, M.A. & Frémeaux-Bacchi, V. (2005) Atypical haemolytic uraemic syndrome and mutations in complement regulator genes.Springer Semin Immunopathol. 27 (3): 359-74. Nilsson, S.C.et al.(2007) A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation.Mol Immunol. 44 (8): 1835-44.

技术参数

产品应用 Flow;IHC(F);WB;ELISA;FN

产品类型单克隆抗体

推荐用于 Flow;IHC(F);WB;ELISA;FN

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Mouse anti Human Complement Factor I 伯乐 人Complement Factor I 抗体 MCA2615

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