mouse anti SLP-76 伯乐 MCA2377 mouse anti SLP-76 MCA2377-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

mouse anti SLP-76 伯乐 MCA2377 mouse anti SLP-76 MCA2377

2024-10-29

mouse anti SLP-76

货号：MCA2377

规格：0.1 mg

市场价格：2550

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：SLP-76

物种：人/小鼠/大鼠

宿主：小鼠

抗体亚型：IgG2b

克隆号：SLP-76/03

荧光染料：Purified

产品介绍
Mouse anti SLP-76 antibody, clone SLP-76/03recognises the SH2 domain-containing leucocyte protein, also known as SLP-76 or Lymphocyte cytosolic protein 2. SLP-76 is a ~76 kDa tyrosine phosphoprotein, expressed primarily by T lymphocytes and cells of the myeloid lineage.SLP-76 is one of several adaptor proteins assisting with TCR-mediated signal transduction, through GRB2 binding, functioning as a substrate for the protein-tyrosine kinase ZAP-70 and thus playing a crucial role in both T cell ontogeny and activation. Other molecules that associate with SLP-76 include phospholipase C (PLC)–gamma, Vav, Nck and fyn binding protein.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution	Phosphate buffered saline
Immunogen	A fusion protein corresponding to amino acids 216-434 of human SLP-76.
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunoprecipitation	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Di Bartolo Vet al.(2007) A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.J Exp Med. 204 (3): 681-91.2.Brockmeyer, C.et al.(2011) T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies themis as a new TCR signalosome component.J Biol Chem. 286: 7535-47.3.Lasserre, R.et al.(2011) Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.J Cell Biol. 195 (5): 839-53.4.Lasserre, R.et al.(2010) Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.EMBO J. 29: 2301-14.5.Paster, W.et al.(2013) GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.J Immunol. 190 (7): 3749-56.

技术参数

产品应用 IP;WB

产品类型单克隆抗体

推荐用于 IP;WB

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mouse anti SLP-76 伯乐 MCA2377 mouse anti SLP-76 MCA2377

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