CD80(B7-1,BB1)和CD86(B7-2,B70)是B7细胞表面配体家族的成员，可调节T细胞激活和免疫应答。CD80在激活的抗原呈递细胞中表达，包括树突细胞、B细胞、单核细胞和巨噬细胞。CD86在休眠单核细胞、树突细胞、激活的B淋巴细胞中表达，在有炎症的情况下进一步上调。CD80和CD86均为CD28的配体，CD28是一种T细胞共刺激受体。CD28与CD80或CD86的相互作用提供初始T细胞激活、T细胞增殖以及获得效应子功能所需的第二信号。或者，CD80和CD86还是CTLA-4的配体，这会导致T细胞活性下调。

产品名称

Anti-CD86 Antibody (FITC), Mouse Monoclonal

经验证的应用

FCM

交叉反应

Reacts with: Rat

特异性

Rat CD86

免疫原

Recombinant Rat CD86 Protein (Catalog#80025-R08H)

制备方法

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD86 (rR CD86; Catalog#80025-R08H; NP_064466.1; Met1-Ile250) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.

来源

Monoclonal Mouse IgG2b Clone #10

纯化

Protein A

缓冲液

Aqueous solution containing 0.5% BSA and 0.09% sodium azide