BIO-RAD MCA5968GA Mouse anti Human CD30, clone C03-8D3,Mouse anti Human CD30, clone C03-8D3-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

BIO-RAD MCA5968GA Mouse anti Human CD30, clone C03-8D3,Mouse anti Human CD30, clone C03-8D3

2024-10-22

Mouse anti Human CD30, clone C03-8D3

货号：MCA5968GA

规格：0.1 mg

价格：2576

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：CD30

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：C03-8D3

荧光染料：Purified

产品介绍
Mouse anti Human CD30, clone C03-8D3,recognizes the human CD30 cell surface antigen also known as TNFRSF8. CD30 is a 120 kDa, type I transmembrane glycoprotein of the tumour necrosis factor (TNF) receptor superfamily. CD30 was originally identified as a molecule expressed on Hodgkin and Reed Sternberg cells in Hodgkin’s disease but has subsequently been detected on certain non-Hodgkin's malignancies as well as some virally transformed cells. It is also expressed on a subset of activated human T-cells, and by a few extrafollicular T and B-cell blasts in normal lymph nodes.Evidence indicates that CD30 may act as a signal transduction molecule. Binding of CD30 by its ligand induces activation of signalling pathways JNK and NF-κB, expression of lymphocyte genes, proliferation and apoptosis (Mutaet al.2000). These and other signalling events of which CD30 is involved contribute to homeostatic regulation of immune responses (Berghellaet al.2011).
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G from ascites
Buffer Solution	Phosphate buffered saline
Immunogen	E. coliderived recombinant protein corresponding to aa 19-595 of human CD30
Fusion Partners	Spleen cells from immunised BALB/C mice were fused with cells of the mouse SP2/0 myeloma cell line
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Muta, H.et al.(2000) CD30 signals integrate expression of cytotoxic effector molecules, lymphocyte trafficking signals, and signals for proliferation and apoptosis.J Immunol. 165 (9): 5105-11.2.Berghella, A.M.et al.(2011) The potential role of thioredoxin 1 and CD30 systems as multiple pathway targets and biomarkers in tumor therapy.Cancer Immunol Immunother. 60 (10): 1373-81.

技术参数

产品应用 Elisa；WB

产品类型 Monoclonal Antibody

推荐用于 Elisa；WB

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BIO-RAD MCA5968GA Mouse anti Human CD30, clone C03-8D3,Mouse anti Human CD30, clone C03-8D3

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