BIO-RAD MCA4746 Mouse anti Rhodopsin,Mouse anti Rhodopsin-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

BIO-RAD MCA4746 Mouse anti Rhodopsin,Mouse anti Rhodopsin

2024-10-22

Mouse anti Rhodopsin

货号：MCA4746

规格：0.1 ml

价格：5848

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Rhodopsin

物种：其它

宿主：小鼠

抗体亚型：IgG1, kappa

荧光染料：Alexa Fluor 488

产品介绍
Mouse anti Rhodopsin antibody, clone 1D4recognizes the sequence TETSQVAPA corresponding to aa 340 to 348 of bovine rhodopsin, a pigment of the retina responsible for the formation of photoreceptor cells and the first events in the perception of light. Rhodopsin consists of the protein opsin and a reversibly bound cofactor, retinal, a photoreactive chromophore. Upon light absorption the 11-cis-retinal is isomerised to all-trans retinal, leading to a change in the shape of rhodopsin. The change activates the associated G protein and triggers a second messenger cascade, eventually resulting in the transmission of a nerve impulse to the brain. The trans-retinal is released and converted back into 11-cis-retinal for re-entry into the cycle.Defects in the gene cause various retinopathies such as retinitis pigmentosa and X-linked congenital stationary night blindness.
产品详情
Target Species	Bovine
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution	10mM HEPES pH7.5, 150mM NaCl
Preservative Stabilisers	0.09% Sodium Azide (NaN3)0.01% Bovine Serum Albumin50% Glycerol
Immunogen	Bovine rhodopsin.
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Molday, R. S.et al.(1983) Monoclonal antibodies to rhodopsin: characterization, cross-reactivity, and application as structural probes.Biochemistry 22: 653-602.MacKenzie, D.et al.(1984) Localization of binding sites for carboxyl terminal specific anti-rhodopsin monoclonal antibodies using synthetic peptides.Biochemistry 23: 6544-93.Molday, R. S.et al.(1987) Peripherin. A rim-specific membrane protein of rod outer segment discs.Invest Ophthalmol Vis Sci. 28: 50-614.Hodges, R. S.et al.(1988) Synthetic peptides define linear antigenic determinants recognized by monoclonal antibodies directed to the cytoplasmic carboxyl terminus of rhodopsin.J Biol Chem 263: 11768-75

技术参数

产品应用 ELISA

产品类型单克隆抗体

推荐用于 ELISA

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BIO-RAD MCA4746 Mouse anti Rhodopsin,Mouse anti Rhodopsin

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