Bio-Rad MCA2455A647 C3a Receptor,Mouse anti Human C3a Receptor:Alexa Fluor 647

2024-10-22

Mouse anti Human C3a Receptor:Alexa Fluor 647

货号:MCA2455A647,MCA2455A647T

规格:100 Tests/1ml,25 Tests/0.25ml

价格:3162,1420

产品类型:流式抗体

品牌:Bio-Rad

抗原:C3a RECEPTOR

物种:人

宿主:小鼠

抗体亚型:IgG1

克隆号:hC3aRZ1

荧光染料:Alexa Fluor 647

产品介绍
Mouse anti Human C3a Receptor antibody, clone hC3aRZ1recognizes the receptor for human complement component C3a (C3aR), a ~55 kDa cell surface protein of the rhodopsin family of G protein-coupled seven-transmembrane receptors. C3a is an anaphylatoxin, which is a potent proinflammatory mediator that possesses immunoregulatory properties. C3a regulates inflammatory functions by binding to the C3a receptor. C3aR is expressed on various tissues and leucocytes including basophils, neutrophils, mast cells, eosinophils and activated T lymphocytes.Expression levels of C3aR on human cells varies significantly between donors.
产品详情
Target SpeciesMouse
Product FormPurified IgG conjugated to Alexa Fluor® 647- liquid
ReconstitutionReconstitute with 1 ml distilled water
Preparation
  • Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Fusion PartnersCells from immunised BALB/c mice were fused with cells of the X63-Ag8.653 myeloma cell line.
AcknowledgementsThis product is provided under an intellectual property licence from Life Technologies Corporation. The transfer of this product is contingent on the buyer using the purchase product solely in research, excluding contract research or any fee for service research, and the buyer must not sell or otherwise transfer this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; (c) manufacturing or quality assurance or quality control, or (d) resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad CA 92008 USA or outlicensing@thermofisher.com
Buffer SolutionPhosphate buffered saline
ImmunogenRecombinant human C3aR protein.
Approx. Protein ConcentrationsIgG concentration 0.05 mg/ml
Preservative Stabilisers0.09%Sodium Azide1%Bovine Serum Albumin
Max Ex/EmFluorophoreExcitation Max (nm)Emission Max (nm)
Alexa Fluor®647650655
RegulatoryFor research purposes only
Guarantee12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application NameVerifiedMin DilutionMax Dilution
Flow CytometryNeat
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Werfel, T.et al.(2000) Activated human T lymphocytes express a functional C3a receptor.J Immunol. 165 (11): 6599-605.2.Soruri, A.et al.(2003) IL-4 down-regulates anaphylatoxin receptors in monocytes and dendritic cells and impairs anaphylatoxin-induced migrationin vivo.J Immunol. 170 (6): 3306-14.3.Zwirner, J.et al.(1999) Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies.Immunology. 97: 166-72.4.Kacani, L.et al.(2001) C5a and C5a(desArg) enhance the susceptibility of monocyte-derived macrophages to HIV infection.J Immunol. 166: 3410-5.5.Raby, A.C.et al.(2009) Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering.J Immunol. 183: 506-17.

技术参数

产品应用 Flow Cytometry

产品类型 单克隆抗体

推荐用于 Flow Cytometry

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