MCA1779GA BIO-RAD Mouse anti Dog CD11d,Mouse anti Dog CD11d-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

MCA1779GA BIO-RAD Mouse anti Dog CD11d,Mouse anti Dog CD11d

2024-10-22

Mouse anti Dog CD11d

货号：MCA1779GA

规格：0.1 mg

价格：22185

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD11d

物种：dog

宿主：小鼠

抗体亚型：IgG1

克隆号：CA11.8H2

荧光染料：Purified

产品介绍
Mouse anti Dog CD11d antibody, clone CA11.8H2recognizes the canine CD11d cell surface antigen, also known as integrin alpha d subunit. The alpha d integrin (CD11d) subunit is expressed as a heterodimer with beta 2 integrin (CD18). CD11d is expressed by a sub-population of macrophages, some CD8 positive T cells and by gamma/delta T cells in the splenic red pulp.Over expression of CD11d is noted in histiocytic disorders including hemophagocytic sarcoma, described as a proliferative disorder specifically of CD11+ macrophages (Moore.et al.2006) with macrophages demonstrating markederythrocytic phagocytosis. Previously, canine histiocytic sarcoma were described as originating entirely from interstitial dendritic cells. Cells from animals with canine hepatosplenic T cell lymphoma (HTSL) strongly express CD11d on malignant cells. Dogs normally demonstrate strong positivity for CD11d on large granular lymphocytes, macrophages and T cells in the splenic red pulp. CD11+ γ/δ T cells constitute ~30% red pulp T cells despite their rarity in peripheral blood, suggesting a splenic red pulp origin of HTSL (Fryet al.2003).
产品详情
Target Species	Dog
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution	Phosphate buffered saline
Immunogen	Affinity purified CD11 antigen from canine spleen.
Preservative Stabilisers	0.09% Sodium Azide (NaN3)
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	1/50
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Danilenko, D.M.et al. (1995) A novel canine leukointegrin, alpha d beta 2, is expressed by specific macrophage subpopulations in tissue and a minor CD8+ lymphocyte subpopulation in peripheral blood.J Immunol. 155:35-44.2.Moore, P.F.et al.(2006) Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages.Vet Pathol. 43:632-45.3.Vernau, W. and Moore, P.F. (1999) An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction.Vet Immunol Immunopathol. 69:145-64.

技术参数

产品应用 Flow

产品类型 Monoclonal Antibody

推荐用于 Flow

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MCA1779GA BIO-RAD Mouse anti Dog CD11d,Mouse anti Dog CD11d

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