Bio-Rad MCA1283PE CD88抗体,mouse anti human CD88:PE-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad MCA1283PE CD88抗体,mouse anti human CD88:PE

2024-10-22

mouse anti human CD88:PE

货号：MCA1283PE

规格：100 Tests

价格：3188

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD88

物种：人

宿主：小鼠

抗体亚型：IgG2a

克隆号：S5/1

荧光染料：PE

产品介绍
Mouse anti Human CD88 antibody, clone S5/1recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone S5/1 was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31) and has recently been shown to recognise the heptameric peptide (D15DKDTLD21).Clone S5/1 has been shown to inhibit the binding of C5a to its receptor.
产品详情
Target Species	Human
Species Cross-Reactivity	Target Species	Cross Reactivity
Rabbit	√
Mustelid	Expected from Sequence
Bovine	√
Ferret	√
Mink	√
N.B. Antibody reactivity and working conditions may vary between species.
Product Form	Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
Reconstitution	Reconstitute with 1.0 ml distilled waterCare should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
Preparation	Purified IgG prepared by affinity chromatography on Protein A
BufferSolution	Phosphate buffered saline
Preservative Stabilisers	0.09% Sodium Azide (NaN3) 1% Bovine Serum Albumin 5% Sucrose
Immunogen	C5aR - peptide: Met1 - Asn31.
Fusion Partners	Spleen cells from immunised BALB/c mice were fused with cells of the X63-Ag8 myeloma cell line.
Max Ex/Em	Fluorophore	Excitation Max (nm)	Emission Max (nm)
RPE 488nm laser	496	578
Regulatory	For research purposes only
Guarantee	12 monthsfrom date of despatch
存储条件
Prior to reconstitution store at +4^oC.After reconstitution store at +4^oC.DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	Neat
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Flow Cytometry Use 10ul of the suggested working dilution to label 1x106cells in 100ul
数据
Mouse anti Human CD88 antibody, clone S5/1(MCA1283) used to stain formalin fixed, paraffin embedded human spleen sections followed by biotinylated anti Mouse IgG and streptavidin alkaline phosphatase (red). Nuclei were counterstained with hematoxylin (blue).
相关产品
Description	Product Code	Applications	Pack Size
Human Seroblock	BUF070A	F	50 Test
Human Seroblock	BUF070B	F	200 Test
同型
Description	Product Code	Applications	Pack Size
Mouse IgG2a Negative Control	MCA929	F	100 Tests
文献
1. Schreiber, A.et al.(2009) C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis.J Am Soc Nephrol. 20: 289-98.2. Eglite, S.et al.(2000) Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils.J Immunol. 165: 2183-9.3. Conroy, A.et al.(2009) C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.PLoS One. 4: e4953.4. Kraft, K.et al.(2001) Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.J Biol Chem. 276: 34408-18.5. Fukuoka, Y.et al.(2008) Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5.J Immunol. 180: 6307-16.6. Bettoni, S.et al.(2017) Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis.J Immunol. 199 (3): 1021-40.7. Huang, L.et al.(2005) Discovery of human antibodies against the C5aR target using phage display technology.J Mol Recognit.18: 327-33.8. Tseng CWet al.(2015) Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin andStaphylococcus aureusSkin Infection.PLoS Pathog. 11 (11): e1005292.

技术参数

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Bio-Rad MCA1283PE CD88抗体,mouse anti human CD88:PE

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