Bio-Rad MCA1281 thyroid stimulating hormone receptor,Thyroid Stimulating Hormone Receptor antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad MCA1281 thyroid stimulating hormone receptor,Thyroid Stimulating Hormone Receptor antibody

2024-10-22

Thyroid Stimulating Hormone Receptor antibody

货号：MCA1281

规格：0.2 mg

价格：3783

产品类型：流式抗体

品牌：Bio-Rad

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：2C11

荧光染料：Purified

产品介绍
Mouse anti Human thyroid stimulating hormone receptor antibody, clone 2C11recognizes the human thyroid stimulating hormone receptor (TSHR) otherwise known as the thyrotropin receptor. TSHR is an important molecule in controlling the growth and function of the normal thyroid.Mouse anti Human thyroid stimulating receptor antibody recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors.Mouse anti Human thyroid stimulating hormone receptor antibody, clone 2C11 recognizes the mutant TSH receptor known as I167N as well as the wild type molecule (Costagliolaet al.1998)
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
BufferSolution	Phosphate buffered saline
Preservative Stabilisers	0.09% Sodium Azide (NaN3)
Immunogen	Recombinant Human TSH receptor.
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Fusion Partners	Spleen cells from immunised BALB/c mice were fused with cells of the NS1/Ag4.1 mouse myeloma cell line.
Regulatory	For research purposes only
Guarantee	12 monthsfrom date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√
ELISA	√
Immunohistology - Frozen	X
Immunoprecipitation	√	5ug/ml	10ug/ml
Western Blotting	√	5ug/ml	10ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
同型
Description	Product Code	Applications	Pack Size
Mouse IgG1 Negative Control	MCA928	F	100 Tests
相关产品
Description	Product Code	Applications	Pack Size
Human Seroblock	BUF070A	F	50 Test
Human Seroblock	BUF070B	F	200 Test
文献
1. Neumann, S.et al.(2011) A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.J Clin Endocrinol Metab. 96: 548-54.2. Narumi Set al.(2011) Nonclassic TSH resistance: TSHR mutation carriers with discrepantly high thyroidal iodine uptake.J Clin Endocrinol Metab. 96 (8): E1340-5.3. Allen, M.D.et al.(2011) Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.FASEB J. 25: 3687-94.4. Chen, C.R.et al.(2001) A full biological response to autoantibodies in Graves' disease requires a disulfide-bonded loop in the thyrotropin receptor N terminus homologous to a laminin epidermal growth factor-like domain.J Biol Chem. 276 (18): 14767-72.5. Read, M.L.et al.(2011) Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment.Cancer Res. 71 (19): 6153-64.6. Krause, K.et al.(2012) Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid.Int J Biochem Cell Biol. 44 (2): 290-301.7. Claus, M.et al.(2005) A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling.Endocrinology. 146 (12): 5197-203.

技术参数

产品应用 Flow;IHC;ELISA;IP；WB

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Bio-Rad MCA1281 thyroid stimulating hormone receptor,Thyroid Stimulating Hormone Receptor antibody

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