Bio-Rad MCA1268EL CD39抗体,Mouse anti Human CD39:Low Endotoxin-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad MCA1268EL CD39抗体,Mouse anti Human CD39:Low Endotoxin

2024-10-22

Mouse anti Human CD39:Low Endotoxin

货号：MCA1268EL

规格：0.5 mg

价格：5143

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD39

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：A1

荧光染料：Low Endotoxin

产品介绍
Mouse anti Human CD39, clone A1recognizes the human CD39 cell surface antigen, a ~70-100 kDa molecule expressed on peripheral blood B cells, T cells and monocytes, and weakly expressed by granulocytes.CD39 has intrinsic ecto-ATPase activity (Wanget al.1996), and expression can be induced on T cells and increased on B cells, as a late activation antigen (Maliszewskiet al.1994).Mouse anti Human CD39, clone A1 has been shown to block MHC independent target cell recognition by hapten-specific CTL (Stocklet al.2001).
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
BufferSolution	Phosphate buffered saline
Preservative Stabilisers	None present
Carrier Free	Yes
Immunogen	PHA activated human lymphocytes
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Endotoxin Level	< 0.01 EU/ug
Fusion Partners	Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line
Regulatory	For research purposes only
Guarantee	12 monthsfrom date of despatch
存储条件
Store at -20oC only.This product should be stored undiluted.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	1/10	1/50
Functional Assays	√
Immunofluorescence	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications fromthe originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Flow CytometryUseUse 10ul of the suggested working dilution to label 10⁶cells or 100ul whole blood.
同型
Description	Product Code	Applications	Pack Size
Mouse IgG1 Negative Control:Low Endotoxin	MCA928EL	CF	0.5 mg
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文献
1. Stöckl, J.et al.(2001) Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL.J Immunol. 167 (5): 2724-33.2. Scholzen, A.et al.(2009) Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta.PLoS Pathog. 5: e1000543.3. Borsellino, G.et al.(2007) Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppressionBlood. 110:1225-32.4. Mittag, D.et al.(2010) The effector T cell response to ryegrass pollen is counterregulated by simultaneous induction of regulatory T cells.J Immunol. 184: 4708-16.5. Loeuillet, C.et al.(2008) In vitro whole-genome analysis identifies a susceptibility locus for HIV-1.PLoS Biol. 6: e32.6. Rawstron, A.C.et al.(2010) Chronic lymphocytic leukaemia (CLL) and CLL-type monoclonal B-cell lymphocytosis (MBL) show differential expression of molecules involved in lymphoid tissue homing.Cytometry B Clin Cytom. 78 Suppl 1: S42-6.7. Alam, M.S.et al.(2009) CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice.J Infect Dis. 199: 494-504.8. Moreno-Fernandez, M.E.et al.(2011) Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism.Blood. 117: 5372-80.9. Guevara-Flores, A.et al.(2008) 5'-p-Fluorosulfonyl benzoyl adenosine inhibits an ecto-ATP-diphosphohydrolase in the tegument surface of Taenia crassiceps cysticerci.Mol Biochem Parasitol. 162: 123-33.10.Glenn, J.R.et al.(2008) Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis.Platelets. 19: 59-69.11. Häusler SFet al.(2014) Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion.Am J Transl Res. 6 (2): 129-39.

技术参数

产品应用 F FN IF

产品类型 Monoclonal Antibody

推荐用于 F; FN; IF

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Bio-Rad MCA1268EL CD39抗体,Mouse anti Human CD39:Low Endotoxin

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