Human Anti-Ranibizumab Antibody, clone AbD16746_hIgG1 BIO-RAD HCA305,Human Anti-Ranibizumab Antibody, clone AbD16746_hIgG1-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human Anti-Ranibizumab Antibody, clone AbD16746_hIgG1 BIO-RAD HCA305,Human Anti-Ranibizumab Antibody, clone AbD16746_hIgG1

2024-10-22

Human Anti-Ranibizumab Antibody, clone AbD16746_hIgG1

货号：HCA305

规格：0.1 mg

价格：4446

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Ranibizumab

物种：其它

宿主：人

抗体亚型：其它

克隆号：AbD16746_hIgG1

荧光染料：其它

产品介绍
Human Anti-Ranibizumab Antibody, clone AbD16746_hIgG1is a paratope specific, inhibitory anti-idiotypic antibody in IgG1 format that recognizes the monoclonal antibody drug ranibizumab. The antibody does not recognize recombinant human vascular endothelial growth factor A (VEGF-A) or ranibizumab when in complex with recombinant human VEGF-A.Clone AbD16746_hIgG1 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a control or calibration standard in an anti-drug antibody (ADA) assay.This antibody also recognizes the monoclonal antibody drug bevacizumab.Ranibizumab (Lucentis) is a humanized Fab fragment antibody (VH3-23/kappa1), originating from the same parental mouse antibody as bevacizumab (Avastin); it has 4 amino acid exchanges in the heavy chain and 1 amino acid exchange in the light chain compared to bevacizumab. Ranibizumab was first approved to treat wet age-related macular degeneration (AMD), a common form of age-related vision loss. It is also approved for the treatment of macular edema following retinal vein occlusion, diabetic macular edema, and diabetic retinopathy. Ranibizumab inhibits angiogenesis by binding to VEGF-A, blocking its interaction with VEGF receptors on the surface of endothelial cells, and thus preventing the subsequent growth of new blood vessels.
产品详情
Product Form	Human IgG1 antibody (lambda light chain) selected from the HuCAL® phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Preparation	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.01% Thiomersal
Affinity	The monovalent intrinsic affinity of AbD16746_hIgG1 was measured as KD= 2 nM by real time, label free molecular interaction analysis on immobilized bevacizumab.
Immunogen	Ranibizumab
Approx. Protein ConcePurityntrations	Antibody concentration 0.5 mg/ml
Acknowledgements	This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.Lucentis is a trademark of Genentech.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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技术参数

产品应用 elisa

产品类型单克隆抗体

推荐用于 elisa

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Human Anti-Ranibizumab Antibody, clone AbD16746_hIgG1 BIO-RAD HCA305,Human Anti-Ranibizumab Antibody, clone AbD16746_hIgG1

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