Human anti Adalimumab, clone AbD18655_hIgE, HCA271 bio-rad ,Human anti Adalimumab, clone AbD18655_hIgE,-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human anti Adalimumab, clone AbD18655_hIgE, HCA271 bio-rad ,Human anti Adalimumab, clone AbD18655_hIgE,

2024-10-22

Human anti Adalimumab, clone AbD18655_hIgE,

货号：HCA271

规格：0.1 mg

价格：5593

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Adalimumab

物种：其它

宿主：人

抗体亚型：IgE

克隆号：AbD18655_hIgE

荧光染料：Purified

产品介绍
Human anti Adalimumab, clone AbD18655_hIgE, is an ultra-high affinity, recombinant anti-idiotypic antibody that specifically recognizes adalimumab monoclonal antibody and inhibits the binding of adalimumab to its target, TNFα. This antibody is derived from the same parent clone asHCA204and has been converted to an IgE isotype.Repeated administration of biotherapeutic drugs can result in the induction of anti-drug antibodies (ADAs), which may affect efficacy of the drug and may cause adverse events including hypersensitivity reactions. Most ADAs have isotype IgG, but ADAs with isotype IgE can potentially elicit anaphylactic reactions. The FDA draft guidance for immunogenicity testing of therapeutic proteins indicates that where the risk of anaphylaxis is a concern, assays should be developed to investigate ADAs with IgE isotype.Clone AbD18655_hIgE is a fully human antibody with isotype IgE, ideal for use as a reference standard in an ELISA to measure IgE ADAs in patient serum.Adalimumab (branded as Humira®) is a fully human monoclonal antibody (IgG1/kappa) approved for the treatment of ankylosing spondylitis, Crohn’s disease, psoriasis and several forms of arthritis. The antibody is specific for TNFα, and acts by blocking the activation of TNF receptors by TNFα. This inactivation down-regulates the inflammatory reactions associated with autoimmune diseases.
产品详情
Product Form	Human IgE antibody (lambda light chain) selected from the HuCAL® phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Preparation	Purified IgE prepared by affinity chromatography
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.01% Thiomersal
Immunogen	Adalimumab (Humira®)
Affinity	The monovalent intrinsic affinity of this antibody was measured as KD=0.06 nM by real time, label-free molecular interaction analysis on immobilized adalimumab
Approx. Protein ConcePurityntrations	Antibody concentration 0.5 mg/ml.
Acknowledgements	This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.Humira is a registered trademark of Abbott Laboratories.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped frozen.When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Mouse anti Human IgE:HRP	MCA2116P	E，WB	0.5mg
文献
1.Wu, Y.,et al.(2013) An electrochemiluminescence (ECL)-based assay for the specific detection of anti-drug antibodies of the IgE isotype.J Pharm Biomed Anal. 86: 73-81.2.Puxeddu, I.,et al.(2016) Hypersensitivity reactions during treatment with biological agents.Clin Exp Rheumatol.34: 129-32.

技术参数

产品应用 elisa

产品类型单克隆抗体

推荐用于 elisa

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Human anti Adalimumab, clone AbD18655_hIgE, HCA271 bio-rad ,Human anti Adalimumab, clone AbD18655_hIgE,

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