Rabbit anti Human Mcl-1 antibody AHP998 bio-rad,Rabbit anti Human Mcl-1 antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti Human Mcl-1 antibody AHP998 bio-rad,Rabbit anti Human Mcl-1 antibody

2024-10-22

Rabbit anti Human Mcl-1 antibody

货号：AHP998

规格：0.1 mg

价格：4692

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Mcl-1

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human Mcl-1 antibodyrecognizes an epitope within the central region (IN) of human Myeloid cell leukaemia sequence 1 (MCL-1), an anti-apoptotic member of the Bcl-2 family of proteins, first identified in differentiating ML-1 myeloid cells, and expressed in many different cell lines, tissues and a variety of tumours.The MCL-1 protein, localised to intracellular membranes and particularly mitochondrial membranes, has since been isolated in two distinct isoforms, known as MCL-1 long (MCL-1L) and MCL-1 short (MCL-1S). MCL-1S has been identified as a pro-apoptotic splice variant of MCL-1L, missing the transmembrane and BH1 and BH2 (Bcl-2 homology) domains. Interaction between these two antagonistic variants can act to regulate cell survival.Rabbit anti Human Mcl-1 antibody (AHP998) recognizes both the MCL-1L (~38 kDa) and MCL-1S (~30 kDa) isoforms of MCL-1.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Buffer Solution	Phosphate buffered saline
Antiserum Preparation	Antisera to human MCL-1 (IN) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Preservative Stabilisers	0.02% Sodium Azide (NaN3)
Immunogen	A 16 amino acid peptide located near the centre of human MCL-1.
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining alquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√	0.5	1.0ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E,WB	1mg
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C,E,WB	1mg
文献
1.ozopas, K.M.et al.(1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.Proc Natl Acad Sci U S A. 90 (8): 3516-20.2.Bae, J.et al.(2000) MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain.J Biol Chem. 275 (33): 25255-61.3.Rinkenberger, J.L.et al.(2000) Mcl-1 deficiency results in peri-implantation embryonic lethality.Genes Dev. 14 (1): 23-7.4.Michels, J.et al.(2005) Mcl-1.Int J Biochem Cell Biol. 37 (2): 267-71.

技术参数

产品应用 wb

产品类型多克隆抗体

推荐用于 wb

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Rabbit anti Human Mcl-1 antibody AHP998 bio-rad,Rabbit anti Human Mcl-1 antibody

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