Rabbit anti Human Caspase-5 antibody AHP965 bio-rad,Rabbit anti Human Caspase-5 antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti Human Caspase-5 antibody AHP965 bio-rad,Rabbit anti Human Caspase-5 antibody

2024-10-22

Rabbit anti Human Caspase-5 antibody

货号：AHP965

规格：0.1 mg

价格：4692

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Caspase-5

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human Caspase-5 antibodyrecognizes an epitope located within the internal region of human Caspase-5, a ~47 kDa cysteine protease, otherwise known as ICH-3. Caspase-5 has been shown to be expressed at higher levels in the colon, lung, spleen, small intestine and by peripheral blood lymphocytes.Caspase-5 is a member of a growing number of inflammatory caspases belonging to the Caspase-1 (ICE-type) subfamily, which require proteolytic processing of their inactive precursor into smaller active subunits. Unlike Caspase-1, Caspase-5 is not directly responsible for the activation of IL-1Beta from the pro-IL-1Beta precursor, but the presence of Caspase-5 does appear to enhance the processing of IL-1Beta.Thein vivoexpression of Caspase-5 is elevated by Lipopolysaccharide (LPS) and gene expression is also increased by Interferon gamma.In vitrocleavage of caspase-5 by the serine protease granzyme B, which plays a major role in cytotoxic T lymphocyte (CTL)-induced apoptosis (Wanget al.1996)
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Antisera to human Caspase-5 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02%Sodium Azide
Immunogen	A 14 amino acid peptide from the centre of human Caspase-5.
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√	1.0ug/ml	2.0ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E,WB	1mg
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C,E,WB	1mg
文献
1.Wang, S.et al.(1996) Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.J Biol Chem. 271 (34): 20580-7.2.Lin, X.Y.et al.(2000) Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma.J Biol Chem. 275 (51): 39920-6.3.Munday, N.A.et al.(1995) Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.J Biol Chem. 270 (26): 15870-6.4.Cohen, G.M. (1997) Caspases: the executioners of apoptosis.Biochem J. 326 ( Pt 1): 1-16.

技术参数

产品应用 wb

产品类型多克隆抗体

推荐用于 wb

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Rabbit anti Human Caspase-5 antibody AHP965 bio-rad,Rabbit anti Human Caspase-5 antibody

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