Rabbit anti NFkB p65 (pSer276) antibody AHP2697 bio-rad,Rabbit anti NFkB p65 (pSer276) antibody

2024-10-22

Rabbit anti NFkB p65 (pSer276) antibody

货号:AHP2697

规格:50 µl

价格:3341

产品类型:免疫组化一抗

品牌:Bio-Rad

抗原:NFkB p65 (pSer276)

物种:其它

宿主:兔

抗体亚型:IgG

荧光染料:Purified

产品介绍
Rabbit anti NFkB p65 (pSer276) antibodyrecognizes nuclear factor NF-kappa-B p65 subunit (NFkB3 p65) also known as transcription factor p65 or RELA, when phosphorylated at serine 276. NFkB p65 is part of the NFkB transcription factor complex that also includes RELB, NFkB1 p105, NFkB1 p50, REL and NFkB2 p52. NFkB p65 regulates expression of a wide variety of genes involved in immune and inflammatory responses (May, M.J. & Ghosh, S. 1997). Protein kinase A (PKA) phosphorylates NFkB p65 on serine 276 and modulates transcriptional activity of NFkB by mediating its interaction with CBP/p300 (Zhong, H. et al. 1998). Serine 276 has also been demonstrated to be phosphorylated by mitogen- and stress- activated protein kinase-1 (MSK1) (Vermeulen, L. et al. 2003). The NFkB pathway plays a critical role in orchestrating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.
产品详情
Target SpeciesHuman
Product FormPurified IgG - liquid
Antiserum PreparationAntiserum to NFkB p65 (pSer276) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer SolutionPhosphate buffered saline
Preservative Stabilisers0.02% Sodium Azide50% Glycerol
ImmunogenPhospho specific-peptide corresponding to residues surrounding serine 276 of human NFkB p65
RegulatoryFor research purposes only
Guarantee12 months from date of despatch
存储条件
Store at -20℃Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application NameVerifiedMin DilutionMax Dilution
Western Blotting1/5001/2000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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技术参数

产品应用 wb

产品类型 Polyclonal Antibody

推荐用于 wb

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