Bio-Rad Furin抗体 AHP2262,Goat anti Human Furin (C-Terminal)-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad Furin抗体 AHP2262,Goat anti Human Furin (C-Terminal)

2024-10-22

Goat anti Human Furin (C-Terminal)

货号：AHP2262

规格：0.1 mg

价格：3383

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Furin

物种：人

宿主：山羊

抗体亚型：IgG

荧光染料：Purified

产品介绍
Goat anti Human furin antibodyrecognizes an epitope within the C-Terminal (CT) region of furin, otherwise known as PACE (Paired basic Amino acid Cleaving Enzyme). Furin is a calcium-dependent serine endoprotease and proprotein convertase, which plays a crucial role in the processing of latent precursor proteins into their biologically active forms, such as during the Notch signaling pathway.The Notch signaling pathway is an evolutionarily conserved pathway in multicellular organisms, vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T cell development, and both tumor progression and suppression.Furin is a critical enzyme during the S1 cleavage of pre-Notch proteins within the golgi apparatus, to convert the nascent form into the mature heterodimeric Notch receptor and the non-covalently associated intracellular domain. These are then transported to the cell surface, in preparation for ligand-receptor binding and further S2 and S3 cleavage, resulting in the release and translocation of the intracellular domain to the nucleus.
产品详情
Target Species	Human
Species Cross-Reactivity	Target Species Cross Reactivity
	Bovine Expected from Sequence
	Rat Expected from Sequence
	Pig Expected from Sequenc
	Dog Expected from Sequence
	Mouse Expected from Sequence
	N.B. Antibody reactivity and working conditions may vary between species.
Product Form	Purified IgG - liquid
AntiserumPreparation	Antiserum to human Furin (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution	TRIS buffered saline
Preservative Stabilisers	<0.1% Sodium Azide (NaN₃)0.5% Bovine Serum Albumin
Immunogen	Synthetic peptide sequence C-EDEGRGERTAFIKDQ, from within the C-Terminal region of Furin (NP_002560.1).
Approx. Protein Concentrations	IgG concentration 0.5mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√	1/128000
Western Blotting	√	0.01	0.03ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Western Blotting AHP2262 detects a band of approximately 110kDa in HEK293 lysate transiently expressing Human Furin tagged with myc and DYKDDDDK.
二抗相关产品
Description	Product Code	Applications	Pack Size
Rabbit anti Goat IgG (Fc):FITC	STAR122F	F	1 mg
Rabbit anti Goat IgG (Fc):HRP	STAR122P	C E WB	1 mg
文献
Further Reading1.Bray, S.J. (2006) Notch signalling: a simple pathway becomes complex.Nat Rev Mol Cell Biol. 7 (9): 678-89.

技术参数

产品应用 E; WB

产品类型 Polyclonal Antibody

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Bio-Rad Furin抗体 AHP2262,Goat anti Human Furin (C-Terminal)

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