Rabbit anti Rat MUNC-18 (pSer515) antibody AHP1234 bio-rad,Rabbit anti Rat MUNC-18 (pSer515) antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti Rat MUNC-18 (pSer515) antibody AHP1234 bio-rad,Rabbit anti Rat MUNC-18 (pSer515) antibody

2024-10-22

Rabbit anti Rat MUNC-18 (pSer515) antibody

货号：AHP1234

规格：0.1 ml

价格：6095

产品类型：免疫组化一抗

品牌：Bio-Rad

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Rat MUNC-18 (pSer515) antibodyrecognizes MUNC-18, also known as syntaxin-binding protein 1, N-Sec1, protein unc-18 homolog 1 (Unc18-1) and p67, when phosphorylated at serine 515. MUNC-18 is a ~67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C.Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release (Kimet al.2006).
产品详情
Target Species	Rat
Product Form	Purified IgG conjugated to Biotin - liquid
Antiserum Preparation	Antisera to rat Munc-18 (pSer515) were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution	10mM Hepes pH7.5
Preservative Stabilisers	0.09%Sodium Azide (NaN3)50%Glycerol0.01%Bovine Serum Albumin
Immunogen	Phosphopeptide corresponding to amino acid sequence surrounding phoshorylated seine 9 of rat GSK3 beta.
Approx. Protein Concentrations	IgG concentration 0.5mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√		1/1000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E,WB	1mg
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C,E,WB	1mg
文献
1.Green, J.B. (2004) Lkb1 and GSK3-beta: kinases at the center and poles of the action.Cell Cycle. 3 (1): 12-4.2.Papkoff, J.et al. (1998) WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells.Biochem. Biophys. Res. Commun. 247:851-8.3.Stambolic, V.et al. (1994) Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.Biochem, J. 303:701-4.4.Garrido, J.et al. (2007) GSK3 alpha and GSK3 beta are necessary for axon formation.FEBS Lett. 581:1579-86.

技术参数

产品应用 wb

产品类型 Polyclonal Antibody

推荐用于 wb

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Rabbit anti Rat MUNC-18 (pSer515) antibody AHP1234 bio-rad,Rabbit anti Rat MUNC-18 (pSer515) antibody

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