Bio-Rad AHP1423 Caspase-2,Rabbit anti Human Caspase-2-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP1423 Caspase-2,Rabbit anti Human Caspase-2

2024-10-22

Rabbit anti Human Caspase-2

货号：AHP1423

规格：50 µg

价格：5593

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：Caspase-2

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
recognises human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family.Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis.In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antiserum to human caspase-2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	<0.1% Sodium Azide (NaN₃)
Approx. Protein Concentrations	IgG concentration 1.0mg/ml
Immunogen	Synthetic peptide corresponding to 6 amino acid sequence from the amino-terminus of human Caspase-2.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Paraffin¹	√		10ug/ml
Western Blotting	√		1ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage. ¹This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Histology Positive Control Tissue Human placenta
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数据
Staining of formalin fixed, paraffin embedded human placenta with Rabbit anti Human caspase-2 (AHP1423)

技术参数

产品应用 IHC(P)*;WB

产品类型 Polyclonal Antibody

推荐用于 IHC(P)*;WB

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Bio-Rad AHP1423 Caspase-2,Rabbit anti Human Caspase-2

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