Bio-Rad AHP1060 CDKN2A,Goat anti Human CDKN2A antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP1060 CDKN2A,Goat anti Human CDKN2A antibody

2024-10-22

Goat anti Human CDKN2A antibody

货号：AHP1060

规格：0.1 mg

价格：5083

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：CDKN2A

物种：人

宿主：山羊

抗体亚型：IgG

荧光染料：Purified

产品介绍
Goat anti Human CDKN2A antibodydetects an epitope within the C-terminal (CT) region of cyclin-dependent kinase inhibitor 2A (CDKN2A). CDKN2A is a ~16 kDa protein belonging to the CDKN2 cyclin dependent kinase inhibitor family. It acts as a negative regulator of cell proliferation by interacting strongly with CDK4 and CDK6, thus inhibiting their ability to interact with cyclin D and to phosphorylate the retinoblastoma protein. CDKN2A is an important tumour suppressor and defects in its production results in tumour formation in a wide range of tissues, including cutaneous malignant melanoma and Li-Fraumeni syndrome.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antisera to CDKN2A (isoform 1) were raised by repeated immunisations of goat with highly purified antigen. Purified IgG prepared by affinity chromatography.
BufferSolution	TRIS buffered saline
Preservative Stabilisers	0.02%Sodium Azide (NaN3) 0.5%Bovine Serum Albumin
Immunogen	Peptide with sequence C-HARIDAAEGPSDIPD from C-terminal of CDKN2A.
Approx. Protein Concentrations	IgG concentration 0.5 mg/ml
Regulatory	For research purposes only
Guarantee	12 monthsfrom dateof despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√		1/32000
Western Blotting	√	0.1	1.0ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications fromthe originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Western Blotting AHP1060 detects a band of approximately 16-18kDa in A431 and Hela cell lysates.
文献
1. Ruas, M. & Peters, G. (1998) The p16INK4a/CDKN2A tumor suppressor and its relatives.Biochim Biophys Acta. 1378 (2): F115-77.2. Piepkorn, M. (2000) Melanoma genetics: an update with focus on the CDKN2A(p16)/ARF tumor suppressors.J Am Acad Dermatol. 42 (5 Pt 1): 705-22; quiz 723-6

技术参数

产品应用 E;WB

产品类型 Polyclonal Antibody

推荐用于 E;WB

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Bio-Rad AHP1060 CDKN2A,Goat anti Human CDKN2A antibody

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