Recombinant Human IL-36α (IL-1F6)
货号：200-36A-10,200-36A-100,200-36A-1000,200-36A-2,200-36A-250,200-36A-500
规格：10ug,100ug,1mg,2ug,250ug,500ug
价格：1425,11123,44543,585,19450,28897
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8), and γ (IL-1F9). IL-36α is highly expressed in psoriatic plaques, as are IL-36β and IL-36γ, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36α is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36α signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36α also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant Human IL-36α is a 17.2 kDa protein containing 154 amino acid residues.来源:E.coli别名:Interleukin-36α, IL36A, Interleukin-1 family member 6 (IL-1F6), FIL1ε (FIL1E), Interleukin-1ε (IL1E)氨基酸序列:MKIDTPQQGS IQDINHRVWV LQDQTLIAVP RKDRMSPVTI ALISCRHVET LEKDRGNPIY LGLNGLNLCL MCAKVGDQPT LQLKEKDIMD LYNQPEPVKS FLFYHSQSGR NSTFESVAFP GWFIAVSSEG GCPLILTQEL GKANTTDFGL TMLF纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Measured by its ability to induce IL-8 secretion by A431 human epidermoid carcinoma cells.Calculated Molecular Weight:17.2 kDaAccession Number:Q9UBH0Gene ID:14440Note:1mg will be provided as 2x500μg.原产地:USA仅用于科研，不能用于临床和诊断。 |
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