CD34 Monoclonal Antibody (MEC 14.7), PE

货号：RM3604

规格：500 µL

价格：2209

产品类型：流式抗体

品牌：Thermo Fisher

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a

克隆号： MEC 14.7

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	0.1-0.25 µg / 1x10^6 cells(Flow)

靶标信息CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

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参考文献：

1.Journal of cell scienceTenascin-C and tenascin-W in whisker follicle stem cell niches: possible roles in regulating stem cell proliferation and migration."RM3604 was used in Immunohistochemistry to show the CD34-positive whisker follicle stem cell niche contains tenascin-C and tenascin-W which may direct their migration and proliferation."2.BloodThe homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis."RM3604 was used in flow cytometry to determine the role of Hhex in hematopoiesis"

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