CD44 Monoclonal Antibody (IM7.8.1), PE

货号：RM5704

规格：500 µL

价格：1327

产品类型：流式抗体

品牌：Thermo Fisher

物种：小鼠

宿主：大鼠

抗体亚型：IgG2b

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	0.1-0.25 µg / 1x10^6 cells (Flow)

靶标信息CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

数据

CD44 Antibody (RM5704) in FlowImmunology letters 2011 -Published figure using CD44 monoclonal antibody (Product # RM5704) in Flow Cytometry

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参考文献：

1.Molecular medicine (Cambridge, Mass.)Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes."RM5704 was used in Flow cytometry/Cell sorting to investigate possible inducers of the malignant transformation of mature T lymphocytes."2.Immunology lettersModeling Sjögren's syndrome with Id3 conditional knockout mice."Published figure using CD44 monoclonal antibody (Product # RM5704) in Flow Cytometry"3.The American journal of pathologyUltraviolet B suppresses immunity by inhibiting effector and memory T cells."RM5704 was used in flow cytometry to elucidate whether UVB exposure inhibits the expansion of effector CD4+ and CD8+ T cells in skin-draining lymph nodes and reduces the number of CD4+ and IFN-gamma+ CD8+ T cells at sites of challenge"4.Journal of immunology (Baltimore, Md. : 1950)Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6."RM5704 was used in flow cytometry to investigate the effect of Stat6 in T cell expansion, survival, and recruitment to the lung"5.Nature immunologyActive recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells."RM5704 was used in flow cytometry to investigate how T cells regulate interleukin 4 expression."

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