CD36 Polyclonal Antibody

货号：PA1-16813

规格：100 µL

价格：5803

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	1:500-1:2,000 (WB)；1:200-1:400 (IHC (P))；1:50-1:200(ICC/IF)

产品详细信息This antibody shares 95% sequence homology with rat.靶标信息CD36 (fatty acid translocase, FAT) is an 88 kDa, ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similar to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids. CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adapter molecules. CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. Further, CD36 may function as a cell adhesion molecule and directly mediates cyto-adherence of Plasmodium falciparum parasitized erythrocytes. Mutations in the CD36 gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the CD36 protein have been found.

数据

CD36 Antibody (PA1-16813) in ICC/IFDetection of CD36 (Green) in HepG2 cells usingProduct # PA1-16813. Nuclei (Blue) were counterstained using Hoechst 33258.

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参考文献：

1.Cell death & diseaseCTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway."Published figure using CD36 polyclonal antibody (Product # PA1-16813) in Western Blot"2.Arteriosclerosis, thrombosis, and vascular biologyHepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis."PA1-16813 was used in Western Blotting to showed that FOXA3 directly bound to the promoter of the Apoa1 gene to regulate its transcription."3.International journal of molecular sciencesHigh-Content Screening of a Taiwanese Indigenous Plant Extract Library IdentifiesSyzygium simileleaf Extract as an Inhibitor of Fatty Acid Uptake."Published figure using CD36 polyclonal antibody (Product # PA1-16813) in Western Blot"4.Stem cell researchHeterogeneity and immunophenotypic plasticity of malignant cells in human liposarcomas."PA1-16813 was used in immunohistochemistry to study the range of malignant cell types present in human liposarcomas"5.Journal of personalized medicineSea-Buckthorn Seed Oil Induces Proliferation of both Normal and Dysplastic Keratinocytes in Basal Conditions and under UVA Irradiation."Published figure using CD36 polyclonal antibody (Product # PA1-16813) in Immunocytochemistry"

技术参数

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