HLA-DR Monoclonal Antibody (LN3)

货号：MA5-11966

规格：500 µL

价格：4733

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG2b

荧光染料：其它

类型:	单抗	同型对照：
浓度：	0.2 mg/mL	用法：	1:100-1:10,000 (WB)；2-4 µg/mL(IHC (F))；Assay-dependent(Flow)

产品详细信息MA5-11966 targets Human MHC II (HLA-DR) in FACS, WB and IHC (F) applications and shows reactivity with Human samples. This antibody does not react with mouse tissue in Western blot applications.The MA5-11966 immunogen is activated human peripheral blood mononuclear cells.靶标信息HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

数据

HLA-DR Antibody (MA5-11966) in IHCFormalin-fixed, paraffin-embedded human tonsil stained with HLA-DR la antibody using peroxidase-conjugate and AEC chromogen. Note membrane staining of B cells and macrophages

推荐产品：

二抗荧光二抗免疫组化一抗标签抗体

参考文献：

1.Frontiers in neurologyHuman Inner Ear Immune Activity: A Super-Resolution Immunohistochemistry Study."MA5-11966 was used in Immunohistochemistry to study the human inner ear and vestibulocochlear nerve."2.Acta neuropathologicaT cell infiltration in both human multiple system atrophy and a novel mouse model of the disease."MA5-11966 was used in Immunohistochemistry to investigate postmortem brain tissue from Multiple system atrophy (MSA) patients and control subjects for evidence of immune activation in the brain."3.Acta neuropathologica communicationsRegulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment."Published figure using HLA-DR monoclonal antibody (Product # MA5-11966) in Immunohistochemistry"4.Journal of neuropathology and experimental neurologyTissue Transglutaminase Appears in Monocytes and Macrophages but Not in Lymphocytes in White Matter Multiple Sclerosis Lesions."MA5-11966 was used in Immunohistochemistry to conclude that TG2 potentially presents a novel target for therapeutic intervention that can support available MS therapies targeting lymphocyte infiltration."5.Neurobiology of agingAmyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism."MA5-11966 was used in immunohistochemistry to study the role of tyrosine kinase activity in the stimulation of microglia by oligomers of beta-amyloid"

技术参数

© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://gibcohyclone.cn/thread-44079.htm