CD3e Monoclonal Antibody (EP449E)

货号：MA5-14482

规格：1 mL

价格：13313

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人/小鼠

宿主：兔

抗体亚型：IgG

克隆号：EP449E

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	1:10-1:100 (WB)；1:125(IHC (P))

产品详细信息MA5-14482 targets CD3E in IHC (P) and Western blot applications and shows reactivity with Human and Mouse samples.The MA5-14482 immunogen is a synthetic peptide corresponding to residues in the cytoplasmic domain of human CD3epsilon. The antibody does not cross react with other subunits of CD3.靶标信息The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

数据

CD3e Antibody (MA5-14482) in IHCFormalin-fixed, paraffin-embedded human tonsil stained with CD3 Epsilon using peroxidase-conjugate and DAB chromogen. Note membrane staining.

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参考文献：

1.HaematologicaImmune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma."MA5-14482 was used in Immunohistochemistry to characterize immunological profiles of diffuse large B-cell lymphoma, and predict the outcome in response to immunochemotherapy."2.Toxicology and applied pharmacologyAlteration of hepatic structure and oxidative stress induced by intravenous nanoceria."MA5-14482 was used in immunohistochemistry to study the effects of intravenous nanoceria on hepatic injury and oxidative stress"3.Journal of hepatologyHepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection."MA5-14482 was used in immunohistochemistry to study the role of CCL17 and CCL22 in Foxp3+ T regulatory cell accumulation at the site of HCV infection"

技术参数

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