CD3e Monoclonal Antibody (UCH-T1)

货号：MA1-21454

规格：100 µg

价格：5809

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号： UCH-T1

荧光染料：其它

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	Assay-dependent (WB)；Assay-dependent(IHC)；Assay-dependent (IHC (F))；Assay-dependent (ICC/IF)；Assay-dependent (Flow)

产品详细信息MA1-21454 detects CD3 in HumanNot suitable for paraffin sections.靶标信息The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

数据

CD3e Antibody (MA1-21454) in IHC (F)Immunohistochemical analysis of CD3e/CD3 epsilon in frozen human tonsil tissue using a CD3e/CD3 epsilon monoclonal antibody (Product # MA1-21454) using the APAAP method.

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参考文献：

1.Arthritis and rheumatismDisease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis."MA1-21454 was used in immunohistochemistry to identify novel disease-specific pathways in spondylarthritis synovitis using geneome-wide microarray analysis"2.PloS oneLong-Term Stable Mixed Chimerism after Hematopoietic Stem Cell Transplantation in Patients with Non-Malignant Disease, Shall We Be Tolerant?"MA1-21454 was used in flow cytometry to test if the two hematopoietic systems in patients with mixed chimerism remain functional and study immunological differences"3.Kidney internationalA revised strategy for monitoring BKV-specific cellular immunity in kidney transplant patients."MA1-21454 was used in flow cytometry to examine the effects of immunosuppressive agents on Polyomavirus BKV-specific T cells"4.Journal of neuroinflammationEvidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis."MA1-21454 was used in flow cytometry to discuss the role of T cells in Rasmussen encephalitis"5.Science (New York, N.Y.)Retention of unassembled components of integral membrane proteins by calnexin."MA1-21454 was used in immunoprecipitation to investigate calnexin's interaction with incompletely assembled TCR components"

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