Human Recombinant GDNF/人重组GDNF
货号：78058,78058.1,78058.2,78058.3
规格：10 μg,100 μg,1000 μg,500 μg
价格：1776,11776,59610,37776
产品类型：细胞因子添加物
品牌：STEMCELL Technologies
| Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily. The GDNF family of growth factors also includes neurturin, persephin, and artemin, which have seven conserved cysteine residues called cysteine-knots (Treanor et al.). GDNF family ligands signal through binding to specific GDNF-family receptor-α (GFRα) co-receptors and activate the RET receptor tyrosine kinase (Durbec et al.). Four different forms of GFRα co-receptors have been characterized (GFRα 1-4); GDNF binds specifically to GFRα1 prior to forming a complex with RET (Airaksinen & Saarma). GDNF is known to promote survival and morphological differentiation of midbrain dopaminergic neurons in both in vivo and in vitro studies and increases their high-affinity dopamine uptake (Granholm et al.; Lin et al.). GDNF has also been shown to have restorative effects on dying dopaminergic neurons in response to degenerative toxins (Aoi et al.). GDNF, together with Human Recombinant BDNF (brain-derived neurotrophic factor; Catalog #78005), BrainPhys™ Neuronal Medium (Catalog #05790), and other supplements, can be used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Bardy et al.). |
数据： |
| （A）通过促进C6细胞增殖测定人重组GDNF的生物活性。用荧光法测定培养7天后细胞增殖情况。 EC50是细胞增殖在最大值的50%时生长因子的有效浓度。上例中 EC50 为 2.17μg/mL。（B）在还原和非还原(-）条件下，用SDS-PAGE对1μg人重组BDNF进行了分离，并用考马斯蓝染色进行染色。人重组GDNF为15.2kda亚基的同二聚体，预测总分子质量为30.4kDa。 |
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