POROS™ XS Strong Cation Exchange Resin,POROS™ XS Strong Cation Exchange Resin/POROS XS强阳离子交换树脂-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

POROS™ XS Strong Cation Exchange Resin,POROS™ XS Strong Cation Exchange Resin/POROS XS强阳离子交换树脂

2024-10-23

POROS™ XS Strong Cation Exchange Resin/POROS XS强阳离子交换树脂

货号：82071,82072

规格：10 mL,50 mL

价格：1983,7252

产品类型：蛋白提取/纯化

品牌：Thermo Fisher

POROS™ XS Strong Cation Exchange Resin is the first high-capacity, high-resolution resin that allows loading to more than 100 mg/mL capacity in the presence of up to 15 mS/cm NaCl, while delivering unprecedented separation capability. A major improvement on traditional cation exchangers, POROS XS resin sets the standard for cation exchange chromatography.• Dynamic binding capacity leads to reduced column size, smaller footprint, decreased buffer usage, and reduced cycling• High resolution supports better product yield and improved impurity clearance• Robust salt tolerance allows improved process flexibility, alignment, and process flow streamlining• Low back pressure and linear pressure responses help improve scalability• Rigid polymeric bead with covalent surface chemistry makes for easier handling and packing, and superior physical and chemical stability, resulting in a robust manufacturing processDynamic binding capacityPOROS XS resin has a high binding capacity of more than 100 mg/mL, at 5% breakthrough, over a broad range of process conditions.Higher dynamic binding capacity was achieved by optimizing the base bead pore structure and surface chemistry.High resolutionUsing an optimized 50 µm particle size, POROS XS resin maintains the superior resolving capacity of POROS™ HS resin while overcoming the challenging impurity levels associated with high titer processes. Resolution is consistent across a wide range of operating flow rates and is maintained independent of protein load.Robust salt tolerancePOROS XS resin has high and consistent protein capacity across a broad range of salt concentrations up to 150 mM NaCl (15 mS/cm conductivity). The ability to load columns under higher conductivity reduces or helps eliminate the dilution of column feed streams or the removal of unit operations, such as tangential flow filtration. The optimized surface ionic capacity of POROS XS resin minimizes competitive binding between the protein of interest and the counterion, resulting in superior salt tolerance.

数据：

5% breakthrough IgG binding capacity vs. salt concentration and pHPOROS XS is able to reach high binding capacity under a wide range of process conditions. Dynamic binding capacity was determined by loading 5 mg/mL IgG solution onto a 3.3 mL column until a 5% breakthrough was reached. The experiment was then repeated using different IgG solutions that varied in NaCl concentration and pH. Experimental conditions: Column: 0.46 cmD x 20 cmL; Buffer: 20 mM MES; Load conditions: 5 mg/mL IgG; Flow rate: 300 cm/hr

IgG binding capacity vs. salt concentrationPOROS XS resin delivers high and consistent protein capacity across a broad range of salt concentrations up to 150 mM NaCl. Dynamic binding capacity was determined by loading a 5 mg/mL IgG solution onto a 3.3 mL column until a 5% breakthrough was reached. The experiment was then repeated using different IgG solutions that varied in NaCl concentration and pH. Experimental conditions: Column: 0.46 cmD x 20 cmL; Buffer: 20 mM MES; Flow rate: 300 cm/hr

技术参数

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POROS™ XS Strong Cation Exchange Resin,POROS™ XS Strong Cation Exchange Resin/POROS XS强阳离子交换树脂

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