Phosphotyrosine Monoclonal Antibody (pY20), FITC

货号：MA1-12441

规格：100μg

价格：4880

产品类型：流式抗体

品牌：Thermo Fisher

物种：其它

宿主：小鼠

抗体亚型：IgG2b, kappa

克隆号：pY20

荧光染料：FITC

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	Assay Dependent(ELISA)；Assay Dependent(IF)；5-10 µg/mL(IHC)；Assay dependent (IP)；Assay dependent(WB)

产品详细信息This antibody does not react with phosphorylated threonine or serine residues.靶标信息The role of tyrosine phosphorylation in transduction of the mitogenic signal from transmembrane receptors and in transformation by oncogene tyrosine kinases has been the subject of intense investigation for several years. While the phosphorylation of specific tyrosine residues has been shown to be a primary mechanism of signal transduction during normal mitogenesis, cell cycle progression and oncogenic transformation, its role in other areas such as differentiation and gap junction communication, is a matter of active and ongoing research. Antibodies that specifically recognize phosphorylated tyrosine residues have proved to be invaluable to the study of tyrosine -phosphorylated proteins and the biochemical pathways in which they function. The fluorescein (FITC) conjugate of clone PY20 anti-phosphotyrosine is especially useful for the detection of these P-Tyr proteins in immunohistochemical and immunocytochemical protocols in situations wherein the use of a secondary antibody would complicate detection of the protein(s) of interest.

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参考文献：

1.The FEBS journalImatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells."MA1-12441 was used in western blot to study the effects of Glivec on breast cancer heparin sulfate proteogycan expression and cell proliferation"AuthorsMalavaki CJ,Roussidis AE,Gialeli C,Kletsas D,Tsegenidis T,Theocharis AD,Tzanakakis GN,Karamanos NK2.Journal of immunology (Baltimore, Md. : 1950)RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells."MA1-12441 was used in western blot to study the role of RhoH in Fc epsilon RI-dependent signal transduction in mast cells"AuthorsOda H,Fujimoto M,Patrick MS,Chida D,Sato Y,Azuma Y,Aoki H,Abe T,Suzuki H,Shirai M3.The Journal of pharmacology and experimental therapeuticsThe combi-targeting concept: dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor activity in vivo."MA1-12441 was used in western blot to study the anti-tumor mechanism of a unimolecular combination of an EGFR tyrosine kinase inhibitor and a DNA damaging triazine"AuthorsMatheson SL,McNamee JP,Wang T,Alaoui-Jamali MA,Tari AM,Jean-Claude BJ4.Cancer researchA fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo."MA1-12441 was used in western blot to investigate the effectiveness of a humanized monoclonal insulin-like growth factor I receptor antibody against human tumor growth"AuthorsBurtrum D,Zhu Z,Lu D,Anderson DM,Prewett M,Pereira DS,Bassi R,Abdullah R,Hooper AT,Koo H,Jimenez X,Johnson D,Apblett R,Kussie P,Bohlen P,Witte L,Hicklin DJ,Ludwig DL5.The Journal of pharmacology and experimental therapeuticsInhibition of epidermal growth factor receptor-mediated signaling by "Combi-triazene" BJ2000, a new probe for Combi-Targeting postulates."MA1-12441 was used in western blot to study the inhibition of EGFR-mediated signaling by a "Combi-triazene" molecule with binary EGFR targeting/DNA-damaging properties"AuthorsBrahimi F,Matheson SL,Dudouit F,McNamee JP,Tari AM,Jean-Claude BJ

技术参数

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