Human IL-2 Recombinant Protein, eBioscience/人IL-2重组蛋白

货号：BMS334

规格：50 µg

价格：10291

产品类型：蛋白表达研究

品牌：eBioscience

产品详细信息Description: Recombinant human IL-2 produced in E.Coli is a single, non-glycosylated mutein (variant form) of human IL-2 polypeptide chain containing 133 amino acids and having a molecular mass of 15385.79 Dalton. eBioscience's rhIL-2 is Des N-Terminal Met and has an Ala substitute for Cysteine at position 126.BMS334 is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is < 0.0645 ng/mL, correspondingto a specific activity of 1.55x107 IU/mg.Purity: >99%.Molecular Weight: 15.4 kDa.靶标信息Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

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