Human IL-6 Recombinant Protein, eBioscience/人IL-6重组蛋白

货号：BMS341

规格：20 µg

价格：3969

产品类型：蛋白表达研究

品牌：eBioscience

产品详细信息Description: Interleukin-6 is a potent lymphoid cell growth factor that affects B-lymphocytes, T-lymphocytes, and hybridoma cells. It will also affect cytotoxic T-cells in combination with other factors such as IL-2 and IFN-gamma. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.Purity: >97%.Molecular Weight: 20.9 kDa.靶标信息Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloidprogenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.

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