HDAC3 Polyclonal Antibody/HDAC3多克隆抗体

货号：PA5-29026

规格：100 µL

价格：4880

产品类型：抗体和染料

品牌：Thermo Fisher

抗原：Synthetic peptide corresponding to a region within

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	多抗	同型对照：
浓度：	1 mg/mL	用法：	Assay-dependent(ChIP)；1:100-1:1000(ICC)；1:100-1:1000(IF)；1:100-1:1000(IHC (P))；1:100-1:500(IP)；1:500-1:3000(WB)

产品详细信息Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, U87-MG, SK-N-SH, IMR32, SK-N-AS, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2, FaDu.Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%).Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.靶标信息Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

数据：

HDAC3 Antibody (PA5-29026) in ICCImmunocytochemistry-Immunofluorescence analysis of HDAC3 was performed in SK-N-SH cells fixed in 4% paraformaldehyde at RT for 15 min. Green: HDAC3 Polyclonal Antibody (Product # PA5-29026) diluted at 1:400. Red: Phalloidin, a cytoskeleton marker. Scale bar = 10 µm. HDAC3 Antibody (PA5-29026) in IHC (P)Immunohistochemical analysis of HDAC3 in paraffin-embedded SW480 xenograft using a HDAC3 polyclonal antibody (Product # PA5-29026) at a dilution of 1:500. HDAC3 Antibody (PA5-29026) in WBWestern blot analysis of HDAC3 using 30 µg of A) 293T (B) A431 (C) H1299 (D) HeLa S3 (E) HepG2 (F) MOLT4 and G) Raji lysate. Samples were loaded onto a 10% SDS-PAGE gel and probed with a HDAC3 polyclonal antibody (Product # PA5-29026) at a dilution of 1:1000.

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