SOX9 Recombinant Rabbit Monoclonal Antibody (7H13L8)/SOX9重组兔单克隆抗体（7H13L8）

货号：702016

规格：100 µg

价格：4809

产品类型：抗体和染料

品牌：Thermo Fisher

抗原：Peptides corresponding to human SOX9 [1) aa4-aa17

物种：人/小鼠

宿主：兔

抗体亚型：IgG

克隆号：7H13L8

荧光染料：其它

类型:	单抗	同型对照：
浓度：	0.5 mg/mL	用法：	2.5 µg/1x10^6 cells(ChIP)；1:100(ICC)；1:100(IF)；2.5 µg/mL(WB)

产品详细信息This antibody is predicted to react with Monkey, Pig, MouseRecombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.靶标信息SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows theprostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.

数据：

SOX9 Antibody (702016) in IFFor immunofluorescence analysis, iPSC differentiated to Intestinal organoids were fixed and permeabilized for detection of endogenous SOX9 using Anti-SOX9 Recombinant Rabbit monoclonal Antibody (Product # 702016, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel b) shows representative cells that were stained for detection and localization of SOX9 protein (green) in the nucleus of cells lining the lumen of intestinal organoids in comparison to iPSC (a). SOX9 Antibody (702016)Antibody specificity was demonstrated by CRISPR-Cas9 mediated knockout of target protein. A loss of signal was observed for target protein in SOX9 (KO) cell line compared to control cell line using Anti-SOX9 Monoclonal Antibody (Product # 702016).

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