Human COX-2 ELISA Kit ELISA试剂盒,Human COX-2 ELISA Kit/人COX-2 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human COX-2 ELISA Kit ELISA试剂盒,Human COX-2 ELISA Kit/人COX-2 ELISA试剂盒

2024-10-23

Human COX-2 ELISA Kit/人COX-2 ELISA试剂盒

货号：EH125RB,EH125RBX5,EH125RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	1.2 ng/mL
检测范围	1.2-300 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	COX2
Protein aliases	COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PHS II, Prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase）
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	COX-2, COX2, GRIPGHS, hCox-2, PGG/HS, PGHS-2, PHS-2, PTGS2
Gene ID	(Human) 5743
Gene symbol	PTGS2
UniProt ID	(Human) P35354

Human COX-2 quantitates human COX-2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human COX-2.人COX-2定量测定血清，血浆，上清液中的人COX-2。该检测试剂盒将专门识别天然和重组人COX-2。Target information 靶标信息COX2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins. The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). It is constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and is up-regulated under pathological conditions, such as in cancer and inflammation (in contrast to the iso-enzyme PTGS1, which is expressed ubiquitously). Up-regulation of COX2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, COX2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. COX2 is naturally inhibited by calcitriol (the active form of Vitamin D). Glucocorticoids chronically trans-repress PTGS2 gene activity in vivo in part by interfering with transcription initiation and elongation. COX2 is a target of NSAID such as aspirin, which can reduce pain and swelling from inflammation driven by COX2.COX2将花生四烯酸酯转化为前列腺素H2（PGH2），这是前列腺素合成（包括生产炎症性前列腺素）中的重要步骤。花生四烯酸酯到前列腺素H2的转化是一个两步反应：将花生四烯酸酯转化成前列腺素G2（PGG2）的环氧合酶（COX）反应和其中PGG2还原为前列腺素H2（PGH2）的过氧化物酶反应。它在某些生理条件下的组织中组成性表达，例如内皮，肾和脑，并在病理条件下上调，例如在癌症和炎症中（与同一种酶PTGS1相比，它无处不在）。 COX2的上调还与细胞粘附增加，表型改变，对凋亡的抗性和肿瘤血管生成有关。在癌细胞中，COX2是前列腺素E2（PGE2）生产中的关键步骤，而前列腺素E2在调节运动性，增殖和抗凋亡性方面起着重要作用。骨化三醇（维生素D的活性形式）天然抑制了COX2。糖皮质激素部分地通过干扰转录起始和延长而在体内慢性反式抑制PTGS2基因的活性。 COX2是NSAID的靶标，例如阿司匹林，可减轻COX2驱动的炎症引起的疼痛和肿胀。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human COX-2 ELISA Kit ELISA试剂盒,Human COX-2 ELISA Kit/人COX-2 ELISA试剂盒

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