PRMT6 Polyclonal Antibody

货号：PA5-80943

规格：100 µL

价格：1698

产品类型：标签抗体

品牌：Thermo Fisher

抗原：A synthetic peptide corresponding to the N-terminu

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:300-1:10000(Flow) ;1:300-1:10000(IF));1:500-1:2000(IHC(P))

产品详细信息This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).This antibody has specificity for Human PRMT6. 靶标信息Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.

数据：

PRMT6 Antibody (PA5-80943) in IFImmunofluorescence staining of PRMT6 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with PRMT6 Polyclonal Antibody (Product # PA5-80943) (1:1000) at 4° C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green).Positive staining was localized to nucleus. PRMT6 Antibody (PA5-80943) in IHC (P)Immunohistochemical staining of human PRMT6 in human breast carcinoma with PRMT6 Polyclonal Antibody (Product # PA5-80943) (1:1000, formalin-fixed paraffin embedded sections).

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技术参数

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