Human LAIR1 ELISA Kit ELISA试剂盒,Human LAIR1 ELISA Kit/人LAIR1 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human LAIR1 ELISA Kit ELISA试剂盒,Human LAIR1 ELISA Kit/人LAIR1 ELISA试剂盒

2024-10-23

Human LAIR1 ELISA Kit/人LAIR1 ELISA试剂盒

货号：EH291RB,EH291RBX5,EH291RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.6 ng/mL
检测范围	0.6-130 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	LAIR1 (CD305)
Protein aliases	CD305, immunoglobulin heavy chain variable region, LAIR-1, leukocyte-associated Ig-like receptor 1, Leukocyte-associated immunoglobulin-like receptor 1
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	CD305, LAIR-1, LAIR1
Gene ID	(Human) 3903
Gene symbol	LAIR1
UniProt ID	(Human) Q6GTX8

Human LAIR1 quantitates human LAIR1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human LAIR1.人LAIR1定量检测血清，血浆，上清液中的人LAIR1。该检测试剂盒专门识别天然和重组人LAIR1。Target information 靶标信息LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.LAIR1（CD305）发挥抑制性受体的作用，对自然杀伤（NK）细胞，B细胞和T细胞的细胞溶解功能起组成型负调控作用。通过Tyr磷酸化的激活导致磷酸酶PTPN6和PTPN11的募集和激活。它也减少了由B细胞受体连接引起的细胞内钙的增加。也可能独立于含SH2的磷酸酶发挥其抑制作用。调节CD4 + T细胞中的细胞因子生成，下调IL2和IFNG生成，同时诱导转化生长因子β的分泌。还下调B细胞中IgG和IgE的产生以及IL8，IL10和TNF的分泌。在这些细胞中，抑制增殖并诱导髓样白血病细胞系凋亡，并防止NF-κBp65亚基/ RELA的核易位和I-κBalpha / CHUK的磷酸化。抑制外周血前体向树突状细胞的分化。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

技术参数

© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://gibcohyclone.cn/thread-46687.htm

特别声明：以上内容(如有图片亦包括在内)来源于授权厂家或网络，如有侵权，请联系删除，本平台不提供信息存储服务。

Notice: The content above (including the pictures if any)comes from authorized manufacturers or networks. In case of infringement, please contact to delete it. This platform does not provide information storage services.

产品询价需求提交

Human LAIR1 ELISA Kit ELISA试剂盒,Human LAIR1 ELISA Kit/人LAIR1 ELISA试剂盒

相关推荐