Human LAMP1/CD107a ELISA Kit ELISA试剂盒,Human LAMP1/CD107a ELISA Kit/人LAMP1 / CD107a ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human LAMP1/CD107a ELISA Kit ELISA试剂盒,Human LAMP1/CD107a ELISA Kit/人LAMP1 / CD107a ELISA试剂盒

2024-10-23

Human LAMP1/CD107a ELISA Kit/人LAMP1 / CD107a ELISA试剂盒

货号：EH294RB,EH294RBX5,EH294RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	1 ng/mL
检测范围	1.229-300 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	LAMP1 (CD107a)
Protein aliases	CD107 antigen-like family member A, CD107a, LAMP-1, lysosomal-associated membrane protein 1, Lysosome-associated membrane glycoprotein 1, lysosome-associated membrane protein 1
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	CD107a, LAMP1, LAMPA, LGP120
Gene ID	(Human) 3916
Gene symbol	LAMP1
UniProt ID	(Human) P11279

Human LAMP1/CD107a quantitates human LAMP1/CD107a in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human LAMP1/CD107a.人LAMP1 / CD107a定量检测血清，血浆，上清液中的人LAMP1 / CD107a。该检测试剂盒将专门识别天然和重组人LAMP1 / CD107a。Target information 靶标信息LAMP1 (CD107a, lysosome-associated membrane protein-1) together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. LAMP1 is a heavily glycosylated membrane protein which contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. LAMP1 is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1, and this mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. Increased LAMP1 immunoreactivity is observed in neurons and glial cells surrounding senile plaques in Alzheimer’s Disease (AD) cases, and is localized in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. LAMP1 is a good marker of mast cell activation.LAMP1（CD107a，溶酶体相关膜蛋白-1）与LAMP-2一起，是溶酶体膜的主要成分，在质膜上也发现了总CD107a的1-2％。 LAMP1是一种高度糖基化的膜蛋白，包含一个假定的信号肽，18个N联糖基化位点，一个跨膜段和一个短的（11个氨基酸）胞质尾巴。 LAMP蛋白参与溶酶体的生物发生，并且是溶酶体与吞噬体融合所必需的。 LAMP1是1型整合膜蛋白，从反高尔基网络转运到内体，然后溶酶体。在细胞激活后，LAMP1转移至质膜取决于carboyxl末端基于酪氨酸的基序（YXXI）。基于酪氨酸的基序相对于膜之间的间隔的扰动消除了LAMP1的溶酶体定位，然后该突变蛋白在质膜和内体之间循环。已经显示细胞表面LAMP1（和LAMP2）促进人外周血单核细胞（PBMC）对血管内皮的粘附，因此，它们可能参与PBMC对炎症部位的粘附。在阿尔茨海默氏病（AD）病例中，老年斑周围的神经元和神经胶质细胞中观察到LAMP1免疫反应性增强，并且在急性胸腺退化中位于髓质上皮细胞，单个巨噬细胞和淋巴细胞中。 LAMP1是肥大细胞激活的良好标志。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

技术参数

© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：https://gibcohyclone.cn/thread-46688.htm

特别声明：以上内容(如有图片亦包括在内)来源于授权厂家或网络，如有侵权，请联系删除，本平台不提供信息存储服务。

Notice: The content above (including the pictures if any)comes from authorized manufacturers or networks. In case of infringement, please contact to delete it. This platform does not provide information storage services.

产品询价需求提交

Human LAMP1/CD107a ELISA Kit ELISA试剂盒,Human LAMP1/CD107a ELISA Kit/人LAMP1 / CD107a ELISA试剂盒

相关推荐