组蛋白乙酰化修饰,多克隆抗体,Phospho-ATF2 (Thr69, Thr51) Polyclonal Antibody

2024-10-24

Phospho-ATF2 (Thr69, Thr51) Polyclonal Antibody

货号:PA5-104804

规格:100 µL

价格:4711

产品类型:标签抗体

品牌:Thermo Fisher

抗原:A synthesized peptide derived from human ATF2 arou

物种:人/小鼠/大鼠

宿主:兔

抗体亚型:IgG

荧光染料:其它

类型:一抗同型对照:
浓度: 1 mg/mL用法:1:100-1:500(ICC);1:100-1:500(IF);1:50-1:200(IHC(P));1:500-1:2000(WB)
靶标信息The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2.
数据:

Phospho-ATF2 (Thr69, Thr51) Antibody (PA5-104804) in IFImmunofluorescent analysis of Phospho-ATF2 (Thr69, Thr51) in HeLa cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-ATF2 (Thr69, Thr51) polyclonal antibody (Product # PA5-104804) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).

Phospho-ATF2 (Thr69, Thr51) Antibody (PA5-104804) in WB Western blot analysis of Phospho-ATF2 (Thr69, Thr51) in various samples (Lane 1: Heat-shock treated MCF7 cells, blocked with antigen-specific peptides, Lane 2: Heat-shock treated MCF7 cells, Lane 3: Heat-shock treated HeLa cells). Samples were incubated with Phospho-ATF2 (Thr69, Thr51) polyclonal antibody (Product # PA5-104804).
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