Human TLR-4 ELISA Kit ELISA试剂盒,Human TLR-4 ELISA Kit/人TLR-4 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human TLR-4 ELISA Kit ELISA试剂盒,Human TLR-4 ELISA Kit/人TLR-4 ELISA试剂盒

2024-10-24

Human TLR-4 ELISA Kit/人TLR-4 ELISA试剂盒

货号：EH460RB,EH460RBX5,EH460RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.4 ng/mL
检测范围	0.4-100 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	TLR4 (CD284)
Protein aliases	CD284, homolog of Drosophila toll, hToll, Toll-like receptor 4
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	ARMD10, CD284, TLR-4, TLR4, TOLL
Gene ID	(Human) 7099
Gene symbol	TLR4
UniProt ID	(Human) O00206

Human TLR-4 quantitates human TLR-4 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human TLR-4.人TLR-4定量检测血清，血浆，上清液中的人TLR-4。该检测试剂盒将只识别天然和重组人TLR-4。Target information 靶标信息TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.TLR4是Toll样受体（TLR）家族的成员，该家族在病原体识别和先天免疫激活中起着基本作用。果蝇对人而言，TLR是高度保守的，并且在结构和功能上相似。该受体在胎盘和白细胞的骨髓单核细胞亚群中最丰富地表达。哺乳动物细胞通过激活TLR4对LPS作出反应。 TLR4属于脂多糖（LPS）受体的多蛋白复合物，包含CD14，LY96和TLR4，并参与大多数革兰氏阴性细菌中脂多糖（LPS）诱导的信号转导事件。 TLR4有助于识别在传染原上表达的病原体相关分子模式（PAMP），并介导有效免疫力发展所必需的细胞因子的产生。各种TLR表现出不同的表达模式。 TLR4基因的突变与LPS反应性的差异有关。另外，已经发现了TLR4基因的几个转录物变体，但是其中大多数的蛋白质编码潜力尚不确定。 TLR4由外周血单核细胞和少量B细胞表达，并且也在人胎盘中表达。 TLR4缺陷小鼠的研究表明TLR的主要配体是脂多糖。因此，这些小鼠还显示出对革兰氏阴性败血症的易感性。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human TLR-4 ELISA Kit ELISA试剂盒,Human TLR-4 ELISA Kit/人TLR-4 ELISA试剂盒

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