组蛋白甲基化修饰,H3K9,多克隆抗体,SUV39H2 Polyclonal Antibody

2024-10-24

SUV39H2 Polyclonal Antibody

货号:PA5-63450

规格:100 µL

价格:5548

产品类型:标签抗体

品牌:Thermo Fisher

抗原:Recombinant protein corresponding to Human SUV39H2

物种:人

宿主:兔

抗体亚型:IgG

荧光染料:其它

类型:一抗同型对照:
浓度: 0.05 mg/mL用法: 1:20-1:50(IHC)
产品详细信息Immunogen sequence: NTVDLEGPPS DFYYINEYKP APGISLVNEA TFGCSCTDCF FQKCCPAEAG VLLAYNKNQQ IKIPPGTPIHighest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87% 靶标信息The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
数据:

SUV39H2 Antibody (PA5-63450) in IHC Immunohistochemical staining of SUV39H2 in human testis tissue shows strong cytoplasmic positivity in subset of cells in seminiferous ducts. Samples were probed using a SUV39H2 Polyclonal Antibody (Product # PA5-63450).
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