组蛋白甲基化修饰,H3K9,多克隆抗体,SUV39H2 Polyclonal Antibody

2024-10-24

SUV39H2 Polyclonal Antibody

货号:PA5-102008

规格:100 µL

价格:4711

产品类型:标签抗体

品牌:Thermo Fisher

抗原:A synthesized peptide derived from human SUV39H2,

物种:人/小鼠

宿主:兔

抗体亚型:IgG

荧光染料:其它

类型:一抗同型对照:
浓度: 1 mg/mL用法: 1:100-1:500(ICC);1:100-1:500(IF);1:500-1:1000(WB)
靶标信息The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
数据:

SUV39H2 Antibody (PA5-102008) in IFImmunofluorescent analysis of SUV39H2 in 293T cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with SUV39H2 polyclonal antibody (Product # PA5-102008) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600.

SUV39H2 Antibody (PA5-102008) in WB Western blot analysis of SUV39H2 in HepG2 cell lysate (Lane 1: treated with the antigen-specific peptide). Samples were incubated with SUV39H2 polyclonal antibody (Product # PA5-102008).
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