Phospho-Aurora B (Thr232) Polyclonal Antibody

货号：PA5-38557

规格：100 µg

价格：4809

产品类型：标签抗体

品牌：Thermo Fisher

抗原：A synthetic phosphopeptide derived from human AurB

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:100-1:500(ICC);1:100-1:500(IF);1:50-1:100(IHC(P));1:500-1:1000(WB)

靶标信息Aurora-B kinase (AurB) is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.

数据：

Phospho-Aurora B (Thr232) Antibody (PA5-38557) in IF Immunofluorescent analysis of Phospho-Aurora B pThr232 in HepG2 cells using a Phospho-Aurora B pThr232 polyclonal antibody (Product # PA5-38557). Phospho-Aurora B (Thr232) Antibody (PA5-38557) in IHC (P)Immunohistochemical analysis of Phospho-Aurora B pThr232 in paraffin-embedded human liver carcinoma using a Phospho-Aurora B pThr232 polyclonal antibody (Product # PA5-38557). Phospho-Aurora B (Thr232) Antibody (PA5-38557) in WB Western blot analysis of Phospho-Aurora B pThr232 in extracts from COS7 cells using a Phospho-Aurora B pThr232 polyclonal antibody (Product # PA5-38557).

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