Human Presenilin 2 ELISA Kit ELISA试剂盒,Human Presenilin 2 ELISA Kit/人Presenilin 2 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human Presenilin 2 ELISA Kit ELISA试剂盒,Human Presenilin 2 ELISA Kit/人Presenilin 2 ELISA试剂盒

2024-10-24

Human Presenilin 2 ELISA Kit/人Presenilin 2 ELISA试剂盒

货号：EH381RB,EH381RBX5,EH381RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6327,28472,54564

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.2 ng/mL
检测范围	0.2-50 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	PSEN2
Protein aliases	AD3LP, AD5, Alzheimer disease 4, E5-1, Presenilin-2, Presenilin-2 CTF subunit, Presenilin-2 NTF subunit, PS-2, STM-2
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	AD3L, AD4, CMD1V, PS2, PSEN2, PSNL2, STM2
Gene ID	(Human) 5664
Gene symbol	PSEN2
UniProt ID	(Human) P49810

Human Presenilin 2 quantitates human Presenilin 2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Presenilin 2.人Presenilin 2定量测定血清，血浆，上清液中的人Presenilin 2。该检测试剂盒将专门识别天然和重组人Presenilin2。Target information 靶标信息Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.具有疾病遗传形式的阿尔茨海默氏病（AD）患者携带早老素蛋白（PSEN1或PSEN2）或淀粉样蛋白前体蛋白（APP）中的突变。这些与疾病相关的突变导致更长形式的β-淀粉样蛋白（在AD脑中发现的淀粉样蛋白沉积的主要成分）的产生增加。假定早老蛋白通过它们对裂解APP的酶γ-分泌酶的作用来调节APP的加工。同样，认为早老蛋白参与Notch受体的切割，使得它们或者直接调节γ-分泌酶的活性，或者本身起蛋白酶的作用。已经鉴定出编码PSEN2的不同同工型的两个交替剪接的转录物变体。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human Presenilin 2 ELISA Kit ELISA试剂盒,Human Presenilin 2 ELISA Kit/人Presenilin 2 ELISA试剂盒

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