Human Presenilin 1 ELISA Kit ELISA试剂盒,Human Presenilin 1 ELISA Kit/人Presenilin 1 ELISA试剂盒

2024-10-24

Human Presenilin 1 ELISA Kit/人Presenilin 1 ELISA试剂盒

货号:EH380RB,EH380RBX5,EH380RBX10

规格:96 tests,5X96 tests,10X96 tests

价格:6327,28472,54564

产品类型:Platinum ELISA

品牌:Thermo Fisher

物种:人

宿主:其它

抗体亚型:其它

荧光染料:其它

灵敏度

10.5 pg/mL

检测范围10.5-2,500 pg/mL

样本类型/体积

血清 50 μL

血浆 50 μL

上清液 50 μL

操作时间

1 hr 20 min

测试时间

4 hr 45 min

Homogenous (no wash)

No

批间变异系数(CV)<12%
批内变异系数(CV)<10%

仪器设备

Colorimetric Microplate Reader 酶标仪

规格

5 x 96 Tests

组份

- 预包被96孔板

- 标准品

- 测定稀释浓缩液

- 生物素化检测抗体

- SAV-HRP

- 洗涤液

- 显色剂

- 终止液

- 胶板盖

储存温度

2-8℃

Protein namePresenilin 1
Protein aliasesPresenilin-1, Presenilin-1 CTF subunit, Presenilin-1 CTF12, Presenilin-1 NTF subunit, Protein S182, PS-1, PS1-CTF12

物种(Tested)

试剂盒类型

Sandwich ELISA Kit

标记(染料)

HRP

检测抗体偶联物Biotin
Gene aliasesAD3, FAD, PS-1, PS1, PSEN1, PSNL1, S182
Gene ID(Human) 5663
Gene symbolPSEN1
UniProt ID(Human) P49768
Human Presenilin 1 quantitates human Presenilin 1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Presenilin 1.人早Presenilin1定量测定血清,血浆,上清液中的人Presenilin1。该检测试剂盒将专门识别天然和重组人Presenilin 1。Target information 靶标信息Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.Presenilin1最初被确定为对早发性阿尔茨海默氏病的易感性标志物。除PEN2,尼卡斯汀和APH-1外,Presenilin1还形成了-γ-分泌酶蛋白复合物,这是一种膜结合的天冬氨酰蛋白酶,可以在脂质双层疏水环境中的肽键处裂解某些蛋白质。这种切割是从几个细胞表面受体发出信号的关键步骤,并且被认为是神经毒性淀粉样肽生成所必需的,而神经毒性淀粉样肽是阿尔茨海默氏病发病机理的核心。像肿瘤坏死因子-α转换酶(TACE)和β-位点切割酶(BACE)蛋白酶家族一样,-γ-分泌酶将切割淀粉样前体蛋白(APP),但在APP的膜内区域内,导致无毒的p3(来自α和-γ切割位点)或有毒的Abeta淀粉样肽(来自β和-γ切割位点)。认为Aβ肽的积累是阿尔茨海默氏病的前体。Presenilin1的多种同工型已知存在。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。

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