SQSTM1 Polyclonal Antibody

货号：PA5-88140

规格：100 µL

价格：4621

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant fusion protein containing a sequence c

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1.17 mg/mL	用法：	1:50-1:100(ICC);1:50-1:100(IF);1:50-1:100(IHC(P));1:20-1:50(IP);1:500-1:2000(WB)

产品详细信息Immunogen sequence: MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPL; Positive Samples: 293T, HeLa, Mouse heart; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Late endosome, Lysosome, Nucleus, P-body, autophagosome 靶标信息This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

数据：

SQSTM1 Antibody (PA5-88140) in ICCImmunocytochemistry-Immunofluorescence analysis of SQSTM1 was performed in U2OS cells using SQSTM1 Polyclonal Antibody (Product # PA5-88140). SQSTM1 Antibody (PA5-88140) in IHC Immunohistochemistry analysis of SQSTM1 in paraffin-embedded human esophagus using SQSTM1 Polyclonal Antibody (Product # PA5-88140) at a dilution of 1:200. SQSTM1 Antibody (PA5-88140) in WB Western Blot analysis of SQSTM1 in extracts from normal (control) and SQSTM1 / p62 knockout (KO) 293T cells using SQSTM1 Polyclonal Antibody (Product # PA5-88140) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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