Human 4-1BB Ligand ELISA Kit ELISA试剂盒,Human 4-1BB Ligand ELISA Kit/人4-1BB配体ELISA试剂盒

2024-10-24

Human 4-1BB Ligand ELISA Kit/人4-1BB配体ELISA试剂盒

货号:EH4RB,EH4RBX5,EH4RBX10

规格:96 tests,5X96 tests,10X96 tests

价格:6641,29884,57271

产品类型:Platinum ELISA

品牌:Thermo Fisher

物种:人

宿主:其它

抗体亚型:其它

荧光染料:其它

灵敏度

0.2 ng/mL

检测范围0.2-50 ng/mL

样本类型/体积

血清 50 μL

血浆 50 μL

上清液 50 μL

操作时间

1 hr 20 min

测试时间

4 hr 45 min

Homogenous (no wash)

No

批间变异系数(CV)<12%
批内变异系数(CV)<10%

仪器设备

Colorimetric Microplate Reader 酶标仪

规格

5 x 96 Tests

组份

- 预包被96孔板

- 标准品

- 测定稀释浓缩液

- 生物素化检测抗体

- SAV-HRP

- 洗涤液

- 显色剂

- 终止液

- 胶板盖

储存温度

2-8℃

Protein name4-1BBL (CD137L)
Protein aliases4-1BB ligand, 4-1BBL, homolog of mouse 4-1BB-L, receptor 4-1BB ligand, tumor necrosis factor (ligand) superfamily member 9, tumor necrosis factor (ligand) superfamily, member 9, tumor necrosis factor ligand 5A, Tumor necrosis factor ligand superfamily member 9

物种(Tested)

试剂盒类型

Sandwich ELISA Kit

标记(染料)

HRP

检测抗体偶联物Biotin
Gene aliases4-1BB-L, CD137L, TNFSF9, TNLG5A
Gene ID(Human) 8744
Gene symbolTNFSF9
UniProt ID(Human) P41273
Human 4-1BB Ligand quantitates human 4-1BB Ligand in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human 4-1BB Ligand.人4-1BB配体定量测定血清,血浆,上清液中的人4-1BB配体。该检测试剂盒将专门识别天然和重组人4-1BB配体。Target information 靶标信息CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.CD137配体(CD137L)是II型膜蛋白,是TNF超家族的一部分。 CD137L是一种共刺激分子,在抗原呈递细胞(DC,单核细胞/巨噬细胞,B细胞)上表达,并在激活后上调。它的受体CD137 / 4-1BB存在于多种细胞中,包括发炎的内皮细胞,其表达增强了表达CD137L的单核细胞的外渗。活化的T细胞还表达CD137,与CD137L的结合可增强T细胞增殖,IL-2分泌,存活和细胞毒性活性。 CD137L还可以在大多数B细胞淋巴瘤上表达,包括套细胞淋巴瘤,滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤(但在霍奇金淋巴瘤和T细胞淋巴瘤上却缺乏)。 CD137L也在癌细胞系中表达,并被认为与T细胞-肿瘤细胞相互作用有关。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。

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