NO66 Polyclonal Antibody

货号：PA5-31439

规格：100 µL

价格：4880

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant fragment corresponding to a region wit

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:500-1:3000(WB)

产品详细信息Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.靶标信息Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt]

数据：

NO66 Antibody (PA5-31439) in WBWestern blot analysis of NO66 using 30 µg of NT2D1 lysate. Samples were loaded onto a 10% SDS-PAGE gel and probed with a NO66 polyclonal antibody (Product # PA5-31439) at a dilution of 1:3000.

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