组蛋白甲基化修饰,H3K4,多克隆抗体,NO66 Polyclonal Antibody

2024-10-24

NO66 Polyclonal Antibody

货号:PA5-18655

规格:100 µg

价格:4880

产品类型:标签抗体

品牌:Thermo Fisher

抗原:Synthetic peptide sequence (GAQHSDSKDPR) correspon

物种:人

宿主:山羊

抗体亚型:IgG

荧光染料:其它

类型:一抗同型对照:
浓度: 0.5 mg/mL用法:0.3-1 µg/mL(WB)
产品详细信息This antibody is predicted to react with mouse and rat based on sequence homology.靶标信息Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt]
数据:

NO66 Antibody (PA5-18655) in WBWestern Blot staining of A431 cell lysate usingProduct # PA5-18655at a concentration of 0.3 µg/mL, the primary antibody incubation was 1 hour and the detection method was chemiluminescence.
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