JMJD1C Polyclonal Antibody

货号：PA5-20804

规格：100 µg

价格：4880

产品类型：标签抗体

品牌：Thermo Fisher

抗原：A 20 amino acid peptide from near the amino termin

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：Alexa Fluor 488

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	20 µg/mL(ICC)；20 µg/mL（IF）；2.5 µg/mL（IHC）；1-2 µg/mL（WB）

产品详细信息A suggested positive control is human liver tissue lysate.PA5-20804 can be used with blocking peptide PEP-0918.靶标信息The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.

数据：

JMJD1C Antibody (PA5-20804) in IHCImmunohistochemical staining of rat liver tissue using a JMJD1C polyclonal antibody (Product # PA5-20804) at a 25 µg/mL dilution. JMJD1C Antibody (PA5-20804) in WBWestern blot analysis of human liver tissue lysate using a JMJD1C polyclonal antibody (Product # PA5-20804) at (A) 1 and (B) 2 µg/mL.

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